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13 janvier 2020

Ph. D. Proposal - Université de Haute-Alsace (Mulhouse): Tomographic Diffractive Microscopy Functionalization

Catégorie : Doctorant

Link to the Ph. D proposal : www.dropbox.com/s/ok6l2ag7wxq36xm/2020_PhDTHTTM.pdf

A Ph. D. position is available at IRIMAS (Université de Haute-Alsace:: Mulhouse: www.irimas.uha.fr/). The topic, at the interface between experimental optics and data-processing, is related to the functionalization of tomographic diffractive microscopes developed at IRIMAS.

Optical microscopy techniques are among the preferred methods for biological studies thanks to their unique capability of imaging living specimens in 3D. Tomographic diffractive microscopy (TDM) [1] is a new marker-less technique, combining micro-holography with tomographic acquisitions. IRIMAS develops this technique in transmission [2-4], in reflection [5], and with specimen rotation [6].

This method makes it possible to extract quantitative absorption and refraction contrast, with an isotropic 3D resolution [6]. However, data acquisition scheme makes dynamic sample’s imaging impossible. On top of sample dynamic behaviour, useful information should be extracted through a functionalized and high-resolution acquisition method.

Extraction of temporally evolving phenomenon as already been demonstrated using interferometric techniques. By dynamically modulating the recorded signal it is possible to operate in Doppler regime [7]. This method belongs to the class of heterodyne holography. Its benefit has already been demonstrated for non-destructive testing [8], and microfluidics [9]. We recently demonstrated that this method can beneficially extract selective information about embryonal blood flow without being disturbed by the flesh signal [10]. However, this information is only reconstructed in a pseudo 3D-volume (mainly due to the depth of field of the technique).


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