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Annonce

20 juillet 2020

Ultrasonic ultrasensitive ultrasound imaging of meniscus vascularization (18 months Post-doc)


Catégorie : Post-doctorant


Post-doctoral position (18 months) in Creatis, Ultrasound team.

 

Context

The project in which this post-doctoral subject is registered concern the meniscus surgery. Indeed, during operations on the meniscus, the surgeon must choose between suturing the meniscus or performing an ablation. Due to the lack of meniscus imaging means in intra-operative situations, the meniscus is most often removed, which leads, in the long run, to various problems of knee degradation and osteoarthritis leading inevitably to the installation of a total knee prosthesis. Thus, preserving the meniscus is essential for the patient's well-being and long-term health [1].

In order to assess the health status of the meniscus, its micro-vascularization have to be evaluated. In the meniscus, three zones of vascularization exist and their quantification is crucial to help the surgeon in his choice. Indeed, depending on the vascularization, a suture of the meniscus would be performed rather than a total ablation. For this, it is necessary, in an endoscopic situation, to evaluate the meniscus vascularisation.

Within the framework of this regional project and in order to measure the meniscus vascularization, two strategies have been identified. The first one is based on photoacoustic imaging (LiPhy) and the second one on ultrasensitive Doppler imaging (Creatis).

 

Objectives

The objective of this post-doctoral project is therefore to propose, develop and validate a method for imaging the micro-vascularization of the meniscus in ultrasound imaging. The validation of the method will be carried out in collaboration with LiPhy on micro-fluidic systems as well as on animal cartilage.

 

Methodology

To carry out this project, ultrafast ultrasound imaging will be used [2]. It allows the medium of interest to be imaged at several thousand images per second and thus evaluate the blood circulation. In order to carry out the ultrasensitive imaging, post-treatments will be necessary to be set up in an automatic or semi-automatic way. A first solution will be based on SVD type wall filters, which have already proved their worth in cerebral ultrasound imaging [3].

All the experimental equipment are available in the laboratory: UlaOp research system and endoscopic probe. In addition, various Doppler settings will be used to test and validate the various developments. Indeed, in anticipation of experiments on animal cartilage, preliminary tests will be carried out on micro-fluidic circuits of different sizes and densities.

In view of clinical use, an effort will be made on real-time data processing to facilitate the future surgeon decision.

 

Collaboration

This post-doctoral project belongs to regional project. Thus, exchanges are to be expected with the various project partners in order to define the optimal characteristics of the ultrasensitive imaging / photoacoustic imaging comparison environment [4] and to be able to perform joint animal meniscus experiments.

 

Skills required

PhD in the field (biomedical engineering, imaging, ultrasound, signal processing).

Keywords: ultrasound imaging, Doppler imaging, SVD filtering

 

Application

The post-doctoral project is supervised by François Varray and Hervé Liebgott.

To apply, send CV, motivation letter and recommendation(s) to François Varray:

francois.varray@creatis.insa-lyon.fr

The beginning of the post-doc will start as soon as possible.

 

References

[1] N. Pujol, O. Barbier, P. Boisrenoult, and P. Beaufils, “Amount of meniscal resection after failed meniscal repair,” Am. J. Sports Med., vol. 39, no. 8, pp. 1648–1652, Aug. 2011, doi: 10.1177/0363546511402661.

[2] L. Petrusca et al., “Fast Volumetric Ultrasound B-Mode and Doppler Imaging with a New High-Channels Density Platform for Advanced 4D Cardiac Imaging/Therapy,” Appl. Sci., vol. 8, no. 2, p. 200, Feb. 2018, doi: 10.3390/app8020200.

[3] C. Demené et al., “Spatiotemporal Clutter Filtering of Ultrafast Ultrasound Data Highly Increases Doppler and fUltrasound Sensitivity,” IEEE Trans. Med. Imaging, vol. 34, no. 11, pp. 2271–2285, Nov. 2015, doi: 10.1109/TMI.2015.2428634.

[4] H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging,” Nat. Biotechnol., vol. 24, no. 7, pp. 848–851, Jul. 2006, doi: 10.1038/nbt1220.

 

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