M2 Internship: ultrasound liver image segmentation using deep learning
2 Octobre 2023
Catégorie : Stagiaire
Ultrasound liver image segmentation using deep learning:
Application to image-guided percutaneous procedure
Image-guided percutaneous methods have been progressively recognized as an efficient alternative for treating Hepatocellular Carcinoma (HCC). Access to organs is ensured by using needles puncturing the skin, which represents the least invasive surgical technique to access deep internal structures into the organs [VLSP18]. However, the effectiveness of needle-based intervention treatment depends on the accuracy of the needle positioning (≈ 3 mm [JBTM18]). Reaching this accuracy is particularly challenging because, contrary to laparoscopic surgery, no direct visual access is permitted.
Non-invasive imaging techniques are required to control the needle's placement efficiently. The most spread imaging modality is the ultrasound (US) due to its low cost, harmlessness (radiation-free), and real-time capabilities. However, the US raises the difficulty of aligning the image's acquisition plan with the needle and the tumor [KSHH15].
Our project, in collaboration with ICube (CNRS Strasbourg), aims at developing a novel solution for needle steering using intra-operative US images and non-rigid registration of a biomechanical model. The biomechanical models will be used to extrapolate the 3D displacement of the volume, even where no imaging data are available. Such an approach can then be used to display with Augmented Reality (AR) 3D information of the organ on top of medical images and automatic needle steering [BCDB20, BaCB21].
Intraoperative images are traditionally used to close the loop-control, but such data are usually incomplete, sparse, and of poor quality. The proposed image-guided percutaneous method requires segmentation of the internal structures of the liver (see Figure 1). In this context, we aim at developing a deep learning (DL) method able to delineate the organ’s anatomy boundary and its internal structure such as vessel or tumor using synthetic data provided by our partner ICube. Then, we will assess the performance of our solution with the actual US B-mode images obtained in real-time. Finally, the segmentation’s output, in conjunction with probe localization, will be reconstructed in 3D, forming the foundation for biomechanics registration.
Master2 in computer science, image processing, AI, applied mathematics, data scientist. Autonomy, open-mindedness and motivation. Some experience in deep learning is appreciated.
The trainee will join the INSERM UMR1101 Laboratory of Medical Information Processing (LaTIM, Brest, France, https://latim.univ- brest.fr). We will work in collaboration with different academic, hospital and company partnerswithin a national project. Access will be given to the computer cluster PLACIS (http://placis.univ-brest.fr/english) and to clinical data from our partners.
Contact and additional information
For application, a CV must be sent to the following e-mails:
[VLSP18] L. Viganò, A. Laurenzi, L. Solbiati, F. Procopio, D. Cherqui, and G. Torzilli, “Open Liver Resection, Laparoscopic Liver Resection, and Percutaneous Thermal Ablation for Patients with Solitary Small Hepatocellular Carcinoma (≤30 mm): Review of the Literature and Proposal for a Therapeutic Strategy,” Dig. Surg., vol. 35, no. 4, pp. 359–371, Jul. 2018.
[JBTM18] T. L. De Jong, N. J. van de Berg, L. Tas, A. Moelker, J. Dankelman, and J. J. van den Dobbelsteen, “Needle placement errors: Do we need steerable needles in interventional radiology?,” Med. Devices Evid. Res., vol. 11, pp. 259–265, 2018.
[KSHH15] J. W. Kim, S. S. Shin, S. H. Heo, J. H. Hong, H. S. Lim, H. J. Seon, Y. H. Hur, C. H. Park, Y. Y. Jeong, and H. K. Kang, “Ultrasound-Guided Percutaneous Radiofrequency Ablation of Liver Tumors: How We Do It Safely and Completely,” Korean J. Radiol., vol. 16, no. 6, p. 1226, Nov. 2015.
[BCDB20] P. Baksic, H. Courtecuisse, C. Duriez, and B. Bayle, “Robotic needle insertion in moving soft tissues using constraint-based inverse Finite Element simulation,” Proc. - IEEE Int. Conf. Robot. Autom., pp. 2407–2413, 2020.
[BaCB21] P. Baksic, H. Courtecuisse, and B. Bayle, “Shared control strategy for needle insertion into deformable tissue using inverse Finite Element simulation,” in IEEE International Conference on Robotics and Automation, 2021, pp. 12442–12448.